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NMN can improve NAD+ metabolic dysregulation after covid-19 infection

NMN can improve NAD+ metabolic dysregulation after covid-19 infection

Aug 18, 2022

On April 29, 2022, the Chinese Academy of Sciences, Peking University and Tsinghua University preclinical research showed that NMN supplementation can rescue NAD+ metabolism, immune response and cell death-related gene expression dysregulation caused by new coronavirus infection, inhibit cell death in mice, and significantly improve Pneumonia caused by viral infection. The research results were included in the authoritative journal "Cell Discovery".



In this study, the researchers found that Covid-19 infection caused genetic dysregulation in mice, and that these dysregulations were associated with NAD+ metabolism, immune response and cell death, which are very similar to the symptoms of Covid-19 patients. With NMNd treatment, the researchers found that, first, the pneumonia phenotype, including excessive inflammatory cell infiltration, hemolysis, and embolism in the lungs infected with COVID-19, was significantly improved. Second, supplementation with NAD+ and NMN significantly inhibited cell death. Even more strikingly, NMN supplementation averted death in 30% of aged mice infected with a lethal dose of Covid-19. Finally, mechanistically, the researchers found that supplementation with NAD+ or NMN could partially rescue the gene expression and metabolic disturbances caused by Covid-19 infection, thereby saving the lives of mice.

The results of this study support a new crown treatment experiment targeting the NAD+ pathway. The NAD+ precursor represented by NMN has become one of the bright spots. Structurally, NMN is the closest to NAD+ and can be converted to NAD+ in just one step. NMN-related industries, as intermediates for new crown treatment drugs, have a huge market and may attract new opportunities.


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Tags : NMN NAD covid-19
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