Magnesium is the second most abundant element in human cells, and it affects hundreds of biochemical reactions in the body by regulating enzyme systems. Many people supplement magnesium in order to improve insomnia, migraine, and relieve stress, but after oral supplementation, magnesium needs to be absorbed through the small intestine and enter the brain, and finally the magnesium content in the brain can be increased to obtain the above benefits. Most of the cheap inorganic magnesium is decomposed into magnesium ions and inorganic salts due to the action of gastric acid. When these decomposed magnesium ions enter the small intestine, it will stimulate small intestinal peristalsis (by affecting intestinal osmotic pressure), resulting in diarrhea, magnesium The example is then excreted with diarrhea rather than being absorbed into the bloodstream by the small intestine. Organic chelated magnesium can avoid the above situation due to its stable structure. They can be absorbed into the blood by the small intestine in a whole form, but facing the blood-brain barrier (the barrier between plasma and cerebrospinal fluid), most of the magnesium is blocked. beyond the barrier. To this end, scientists conducted a lot of screening and testing, and finally locked in magnesium L-threonate: it is the only magnesium supplement that can pass the blood-brain barrier, which means that it can effectively increase the level of magnesium ions in the brain.

A 2015 randomized, double-blind, placebo-controlled study of 44 participants with mild cognitive impairment (aged 50-70 years) supplemented with 2 grams of magnesium threonate daily, results after 3 months showed that their brains reversed aging by an average of 9.4 years.