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Prostaglandin Series

ALPROSTADIL 745-65-3

ALPROSTADIL 745-65-3

95% up, USP26
  • Product Details

Product Information


Product name

Alprostadil

Molecular Formula

C20H34O5

Molecular Weight

354.48

CAS No.

745-65-3

Quality Standard

95% up, USP26

Appearance

White powder


COA of Alprostadil


Items

Specifications

Results

Appearance

White to off-white powder

Complies

Identification

HPLC retention time of sample complies with that of known sample

Complies

Water

≤0.5%

0.03%

Residual solvents

≤0.5%

0.02%

Residual on ignition

≤0.5%

0.20%

Related substances

PGAI:≤0.5%

Undetected

PGBI:≤0.5%

Undetected

13,14-Dihydro-PGEI: ≤0.5%

Undetected

Other impurities: ≤ 0.5%

Undetected

Assay

95.0%~105.0%

99.00%


Usage


Function of Alprostadil
Alprostadil, alias PGE1. PGE1 is a biologically active substance widely present in the body, the mechanism of treating diabetic neuropathy:

1. Improve hemodynamics, increase the CAMP content in vascular smooth muscle cells, exert its vasodilator effect and reduce peripheral resistance;

2. To improve blood rheology, PGE can inhibit platelet aggregation, reduce platelet high response and thromboxane A (TXA) level, inhibit platelet activation, promote the reversal of activated platelets around thrombus, and improve the deformability of red blood cells;

3. PGE can activate lipoproteinase and promote triglyceride hydrolysis, reduce blood lipids and blood viscosity;

4. PGE can stimulate vascular endothelial cells to produce tissue-type fibrinolytic substance (t-PA), which has a certain direct thrombolytic effect.

5. By inhibiting free Caz of vascular smooth muscle cells and inhibiting the release of norepinephrine from vascular sympathetic nerve endings, the vascular smooth muscle is relaxed and the microcirculation is improved.

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