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6-Benzofurancarboxylic acid 77095-51-3

6-Benzofurancarboxylic acid 77095-51-3

99% up by HPLC
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Product Information


Product name

6-Benzofurancarboxylic acid

Systematic name

1-benzofuran-6-carboxylic acid; Benzofuran-6-carboxylic acid; LIFI-009; Lifitegrast intermediate

CAS No.

77095-51-3

Molecular Formula

C9H6O3

Molecular Weight

162.145

Quality Standard

99% up

Appearance

White powder


Usage


6-Benzofurancarboxylic acid is one of the key intermediates of Lifitegrast.


Function of Lifitegrast

Lifitegrast is a leukocyte function antigen 1 antagonist used in the treatment of dry eye. Lifitegras can bind to leukocyte functional antigen 1 (LFA-1), preventing the binding of LFA-1 to its cognate ligand intercellular adhesion molecule-1 (ICAM-1). ICAM-1 is overexpressed in the corneal Chemicalbook membrane and conjunctival tissues of patients with dry eye, and LFA-1 binds to ICAM-1 to promote the formation of immune synapses, leading to activation of T cells and migration to target tissues. In vitro studies have shown that Lifitegrast can inhibit T cell adhesion to ICAM-1 and also inhibit the secretion of inflammatory cytokines in human peripheral blood mononuclear cells.

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