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Vonoprazan Fumarate 1260141-27-2 Vonoprazan Fumarate 1260141-27-2

Vonoprazan Fumarate 1260141-27-2
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Basic information of Vonoprazan fumarate:

Name

Vonoprazan fumarate

Alias

TAK 438, Vonoprazan; TAK-438; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate; Vonoprazan FuMarate; Vonoprazan-025-Salt2; Vonaprazan; vonoprazan(tak-438)1260141-27-2; fuMarate vonoprazan

CAS NO.

1260141-27-2

Molecular Formula

 C21H20FN3O6S

Molecular Weight

461.4634032

Grade Standard

Medicine grade  / 99% min / GMP/ PMDA / DMF

Package Size

10g/bag; 1kg/bag; 10kg/tin; 25kg/drum

Storage:

Keep in a well-closed container, protected from light and stored at a temperature of 2 to 8


Use of Vonoprazan fumarate: 

Vonoprazan fumarate is used for the treatment of erosive esophagitis, gastric ulcer, duodenal ulcer. Compared to traditional irreversible proton pump inhibitors (such as omeprazole, esomeprazole, etc.), Takecab has the following advantages:
1 rapid onset, the first day of administration will achieve the maximum acid suppression effect;
2 oral administration, not affected by gastric acid destruction, need to be made into enteric drug delivery form;
3 There is a certain improvement in the phenomenon of acid breakthrough at night.

COA of Vonoprazan fumarate:

Item

Standard

Result

Appearance

White or off-white crystalline powder odorless, bitter taste 

Conforms 

IR Absorption

Consist with the spectra obtained with Cimetidine CRS. 

Conforms

UV Absorption

Should conform 

Conforms

Heavy metal

≤20ppm

<20ppm

Residue on ignition

≤0.2%

0.02%

Related substances 

Single impurity≤0.2%

0.15%

Total impurity≤1.0%

0.47%

Loss on drying 

≤1.0%

0.06%

Organic volatile impurities

(ethanol) (loss on drying)

≤0.5%

0.06%

Assay (calculated with

reference on dried substance)

98.0-102.0%

99.60%


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MORE_DETAIL Vonoprazan Fumarate 1260141-27-2

Basic information of Vonoprazan fumarate:

Name

Vonoprazan fumarate

Alias

TAK 438, Vonoprazan; TAK-438; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate; Vonoprazan FuMarate; Vonoprazan-025-Salt2; Vonaprazan; vonoprazan(tak-438)1260141-27-2; fuMarate vonoprazan

CAS NO.

1260141-27-2

Molecular Formula

 C21H20FN3O6S

Molecular Weight

461.4634032

Grade Standard

Medicine grade  / 99% min / GMP/ PMDA / DMF

Package Size

10g/bag; 1kg/bag; 10kg/tin; 25kg/drum

Storage:

Keep in a well-closed container, protected from light and stored at a temperature of 2 to 8


Use of Vonoprazan fumarate: 

Vonoprazan fumarate is used for the treatment of erosive esophagitis, gastric ulcer, duodenal ulcer. Compared to traditional irreversible proton pump inhibitors (such as omeprazole, esomeprazole, etc.), Takecab has the following advantages:
1 rapid onset, the first day of administration will achieve the maximum acid suppression effect;
2 oral administration, not affected by gastric acid destruction, need to be made into enteric drug delivery form;
3 There is a certain improvement in the phenomenon of acid breakthrough at night.

COA of Vonoprazan fumarate:

Item

Standard

Result

Appearance

White or off-white crystalline powder odorless, bitter taste 

Conforms 

IR Absorption

Consist with the spectra obtained with Cimetidine CRS. 

Conforms

UV Absorption

Should conform 

Conforms

Heavy metal

≤20ppm

<20ppm

Residue on ignition

≤0.2%

0.02%

Related substances 

Single impurity≤0.2%

0.15%

Total impurity≤1.0%

0.47%

Loss on drying 

≤1.0%

0.06%

Organic volatile impurities

(ethanol) (loss on drying)

≤0.5%

0.06%

Assay (calculated with

reference on dried substance)

98.0-102.0%

99.60%

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