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Nintedanib intermediate 14192-26-8 Nintedanib intermediate 14192-26-8

Nintedanib intermediate 14192-26-8
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Basic information of Nintedanib intermediate 14192-26-8 :

Name

Nintedanib intermediate 14192-26-8

Methyl 2-oxoindole-6-carboxylate

Oxindole-6-carboxylic acid methyl ester

Appearance:

White or off-white powder

CAS NO.

14192-26-8

MolecularFormula

C10H9NO3

Molecular Weight

262.35

Grade Standard

98% by HPLC

Single Impurity

0.1% below

Package Size

25kg/drum


Use of Nintedanib intermediate 14192-26-8: 


Nintedanib intermediate 14192-26-8 is a key intermediate for Nintedanib .

Nidanib targets platelet-derived growth factor receptors (PDGF alpha and beta), fibroblast growth factor receptor (FGFR1-3), vascular endothelial growth factor receptor (VEGFR1-3), and adenosine triphosphate with these receptors. (ATP) competitive binding of binding sites, blocking the signaling pathway of fibrosis, inhibiting the spread, metastasis and transformation of fibroblasts, thereby slowing the progression of idiopathic pulmonary fibrosis (IPF) disease.

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MORE_DETAIL Nintedanib intermediate 14192-26-8

Basic information of Nintedanib intermediate 14192-26-8 :

Name

Nintedanib intermediate 14192-26-8

Methyl 2-oxoindole-6-carboxylate

Oxindole-6-carboxylic acid methyl ester

Appearance:

White or off-white powder

CAS NO.

14192-26-8

MolecularFormula

C10H9NO3

Molecular Weight

262.35

Grade Standard

98% by HPLC

Single Impurity

0.1% below

Package Size

25kg/drum


Use of Nintedanib intermediate 14192-26-8: 


Nintedanib intermediate 14192-26-8 is a key intermediate for Nintedanib .

Nidanib targets platelet-derived growth factor receptors (PDGF alpha and beta), fibroblast growth factor receptor (FGFR1-3), vascular endothelial growth factor receptor (VEGFR1-3), and adenosine triphosphate with these receptors. (ATP) competitive binding of binding sites, blocking the signaling pathway of fibrosis, inhibiting the spread, metastasis and transformation of fibroblasts, thereby slowing the progression of idiopathic pulmonary fibrosis (IPF) disease.
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