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Dinoprostone 363-24-6 Dinoprostone 363-24-6

Dinoprostone 363-24-6
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Basic information of Dinoprostone/Prostaglandin E2 :

Name

Dinoprostone

Alias

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid;(5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID;PROSTAGLANDIN;

CAS NO.

363-24-6

Molecular Formula

C20H32O5

Molecular Weight

352.47

EINECS

206-656-6

Brief Introduction

Dinoprostone is a natural prostaglandin (PG) and has a contractile effect on the uterus during each pregnancy. However, the sensitivity of the gestational uterus to PGE2 is inconsistent during each pregnancy.


Use of Dinoprostone:

Dinoprostone/PGE2 is different from oxytocin. It has a stimulatory effect on the uterus during each pregnancy and is mild. The systolic function is 10 to 40 times stronger than PGE2α. It can transform and dilate the cervix and can be used to dilate the cervix before surgery. This may be due to the prostaglandin stimulation of cervical fibroblasts, which is caused by the altered arrangement of collagen fibers. It can relax the bronchial smooth muscle and warm up the hypothalamic thermoregulatory center. After the administration, the body temperature can be increased by 1~2°C. Intravaginal or intraamniotic administration can also cause early and mid-term pregnancy uterine excitement and lead to miscarriage, can be used for induction of labor in mid-term pregnancy, full-term pregnancy induced labor and therapeutic abortion, and pregnancy toxemia (preeclampsia, hypertension ), pregnant patients with kidney disease, prolonged pregnancy, fetal death, vesicular-like mass, premature rupture of the amniotic membrane, the elderly can be applied.

COA of Dinoprostone :

Items

Specifications

Results

Appearance

White to whitish crystal powder

Conforms

Loss on drying

NMT 0.5%

0.33%

Residue on ignition

NMT 0.1%

Conforms

Heavy metal

NMT 20ppm

Conforms

Assay (HPLC)

NLT 99.5%

99.77%

Related substances

NMT 0.5%

0.23%

Single impurity

NMT 0.1%

0.07%

Conclusion: Complies to the Enterprise standard



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MORE_DETAIL Dinoprostone 363-24-6

Basic information of Dinoprostone/Prostaglandin E2 :

Name

Dinoprostone

Alias

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid;(5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID;PROSTAGLANDIN;

CAS NO.

363-24-6

Molecular Formula

C20H32O5

Molecular Weight

352.47

EINECS

206-656-6

Brief Introduction

Dinoprostone is a natural prostaglandin (PG) and has a contractile effect on the uterus during each pregnancy. However, the sensitivity of the gestational uterus to PGE2 is inconsistent during each pregnancy.


Use of Dinoprostone:

Dinoprostone/PGE2 is different from oxytocin. It has a stimulatory effect on the uterus during each pregnancy and is mild. The systolic function is 10 to 40 times stronger than PGE2α. It can transform and dilate the cervix and can be used to dilate the cervix before surgery. This may be due to the prostaglandin stimulation of cervical fibroblasts, which is caused by the altered arrangement of collagen fibers. It can relax the bronchial smooth muscle and warm up the hypothalamic thermoregulatory center. After the administration, the body temperature can be increased by 1~2°C. Intravaginal or intraamniotic administration can also cause early and mid-term pregnancy uterine excitement and lead to miscarriage, can be used for induction of labor in mid-term pregnancy, full-term pregnancy induced labor and therapeutic abortion, and pregnancy toxemia (preeclampsia, hypertension ), pregnant patients with kidney disease, prolonged pregnancy, fetal death, vesicular-like mass, premature rupture of the amniotic membrane, the elderly can be applied.

COA of Dinoprostone :

Items

Specifications

Results

Appearance

White to whitish crystal powder

Conforms

Loss on drying

NMT 0.5%

0.33%

Residue on ignition

NMT 0.1%

Conforms

Heavy metal

NMT 20ppm

Conforms

Assay (HPLC)

NLT 99.5%

99.77%

Related substances

NMT 0.5%

0.23%

Single impurity

NMT 0.1%

0.07%

Conclusion: Complies to the Enterprise standard


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