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Polymyxin B Sulphate 1405-20-5

Polymyxin B Sulphate 1405-20-5

6500IU/MG up, USP
  • Product Details

Product Information


Product name

Polymyxin B Sulphate

CAS No.

1405-20-5

Molecular Formula

C56H100N16O17S

Molecular Weight

1301.56

Quality Standard

6500IU/MG up /Medicine Grade

Appearance

White powder


COA of Polymyxin B Sulphate


ITEMS

SPECIFICATION

RESULTS

DESCRIPTION

WHITE TO ALMOST WHITE POWDER, HYGROSCOPIC.

CONFORMS

SOLUBILITY

FREELY SOLUBLE IN WATER; SLIGHTLY SOLUBLE IN ALCOHOL.

CONFORMS

IDENTIFICATION

A. LIQUID CHROMATOGRAPHIC IDENTIFICATION TEST

B. A REDDISH VIOLET COLOR IS PRODUCED

C. TEST FOR SULFATE

CONFORMS

PH(2%)

5.0~7.0

5.7

PH(0.5%)

5.0~7.5

5.5

SPECIFIC ROTATION

-78°-   -90°

-80.0°

LOSS ON DRYING

NOT MORE THAN 7.0%

4.7%

PHENYLALANINE

9.0%~12.0%

10.31%

SULPHATED ASH

NOT MORE THAN 0.75%

0.31%

SULPHATE

15.5%~17.5%

16.53%

HEAVY METALS

NOT MORE THAN 20PPM

<20PPM

ASSAY(MICROBIAL)

(ON DRIED BASIS)

NOT LESS THAN 6500IU/MG

8220 IU/MG

PARTICLE SIZE

99.0%:NOT MORE THAN 30UM BY VOL.

90.0%:NOT MORE THAN 25UM BY VOL.

75.0%:NOT MORE THAN 20UM BY VOL.

MEAN DIAMETER:NOT MORE THAN 8.0UM

 

 

CONFORMS

CONCLUSION:THE RESULTS CONFORM TO THE STANDARD OF USP34


Usage


Function of Polymyxin B Sulphate

Polymyxin B sulphate is similar to polymyxin E. It can inhibit gram-negative bacilli such as Escherichia coli, Pseudomonas aeruginosa, Para Escherichia coli, Klebsiella pneumoniae, Acidophilus, Pertussis and Shigella, etc. Or bactericidal effect. It is mainly used for Pseudomonas aeruginosa and other Pseudomonas to cause the wounds, urinary tract, eyes, ears, trachea and other parts of the Chemicalbook infection. It can also be used for sepsis and peritonitis. And resistant to aminoglycosides, resistant to third-generation cephalosporin bacteria and Pseudomonas aeruginosa or other sensitive bacteria caused by serious infections, such as bacteremia, endocarditis, pneumonia, post-burn infections, etc.


Polymyxin B is a peptide antibiotic against gram-negative bacilli, which can change the membrane structure to leak small molecules and inhibit the growth of gram-negative bacteria. Has a bactericidal effect on E. coli Chemicalbook. Binds to the lipid A portion of bacterial lipopolysaccharides. Inducing small holes in the outer cell membrane. Mode of action: Combine and interfere with the permeability of the cell plasma membrane. Antibacterial spectrum: Gram-negative bacteria.

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