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Introduction to the Pharmacological Effects of Glutathione Introduction to the Pharmacological Effects of Glutathione

Glutathione is present in all animal cells and is composed of glutamic acid, cysteine and glycine in human cells, and is present in its normal form in its thiol reduced form. It is a prosthetic group of glyceraldehyde phosphate dehydrogenase and a coenzyme of glyoxalase and triose phosphate dehydrogenase. It plays a direct or indirect role in many life activities, participates in the body's tricarboxylic acid cycle and sugar metabolism, enables the body to obtain high energy, and can activate a variety of enzymes.Glutathione plays a direct or indirect role in many life activities. These effects include natural antioxidants that fight against human aging, infection, poisoning, and exogenous toxins. It also has an effect on gene expression, regulation, oxidative stress, fermentation activity, and metabolic regulation. At the same time, it has effects on cell protection, amino acid transport, immune function regulation, and promotion of sugar, fat and protein metabolism. It can also affect the metabolic processes of cells. The active ingredient of glutathione is reduced glutathione, and reduced glutathione accounts for about 95% of the components of glutathione. The role of reduced glutathione is mainly involved in the redox process in the body, combined with peroxides and free radicals to prevent the destruction of sulfhydryl groups by oxidants, and to protect the thiol-containing proteins and thiol-containing enzymes in the cell membrane from damage. In particular, it has the functions of protecting liver cells, promoting liver enzyme activity, anti-oxidation and detoxification, and also counteracting damage of important organs by free radicals. In recent years, glutathione has been widely used in the adjuvant treatment of malignant tumors, hypertension, liver disease, atherosclerosis, radiation stomatitis, HIV, acute poisoning, tumor and chemotherapy, lung injury, nephrotic syndrome and many other diseases. As clinicians continue to deepen their research on glutathione, the clinical application of this drug is becoming more widespread.
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