Enzymes and co-enzymes, as biocatalysts, are often used in the manufacture of drugs and health products. Enzymatic method is also popular in the industry. The related preparation methods can effectively control the quality of final products, improve production, and reduce waste and by-products, bringing a breakthrough impact on the bio-manufacturing industry. Compared with traditional chemical manufacturing methods, enzymatic reaction conditions are mild, and there is no need to use highly polluted chemicals and harsh high-temperature and high-pressure chemical reaction conditions. Enzymes are non-toxic and can be rapidly decomposed. However, in the fine chemical industry, daily chemical industry and pharmaceutical industry, only less than 4% of them are prepared by enzymatic method.
The production of nicotinamide mononucleotides by fermentation in Japan is very environmentally friendly, but the process is complex, time-consuming and labor-consuming, and the production cost is very high. Nicotinamide riboside (NR), another precursor of nicotinamide adenine dinucleotide (NAD) produced by chemical method in the United States, is difficult to avoid chemical residues. It also needs to be transformed into nicotinamide mononucleotide (NMN)
before it can be transformed into NAD. The conversion rate is much lower than that of nicotinamide mononucleotide. After years of unremitting efforts and research, technicians in Hong Kong, China have successfully developed new enzymes and patented technologies, and applied them to the preparation of anti-aging products, nicotinamide mononucleotide (NMN). The new process can greatly reduce production costs, solid waste and energy consumption, and make expensive products more affordable to the public.