Reduced glutathione (GSH) is mainly synthesized in the liver and is widely distributed in various organs of the body. It plays an important role in maintaining the biological function of cells. Its molecule contains sulfhydryl groups, which can protect liver cells in many ways. The drug can bind to peroxides and free radicals in the body, and has the function of fighting oxidants to destroy sulfhydryl groups and organs, and protecting thiol-containing proteins and enzymes in cells. It has functions such as detoxification and inactivation of hormones. It can promote the metabolism of bile acid, which is good for the absorption of fat and fat-soluble vitamins in the digestive tract. It has a certain antiviral effect. Appropriate supplementation of exogenous GSH can prevent, alleviate and stop the damage of tissue cells and change the pathophysiological process.
Hepatoprotective drugs can be divided into non-specific anti-inflammatory drugs (glycyrrhizic acid preparations), detoxification drugs (reduced glutathione
, tiopronin, etc.), hepatocyte membrane repair protectants (polyene phosphatidylcholine), and antibiotics oxidizing drugs (silibinin, etc.), choleretic drugs (S-adenosylmethionine, ursodeoxycholic acid, anthranil trisulfide, etc.), and enzyme-lowering liver (biphenyl diester, bicyclol).
Different liver-protecting drugs have different mechanisms of action and different sites of action. The drug should be selected according to the cause, the disease period and the condition. It is generally not recommended to use a drug with the same or similar ingredients. The types of anti-inflammatory and hepatoprotective drugs used at the same time should not be excessive. Usually choose 1-2 anti-inflammatory and liver-protecting drugs. At most, there are usually no more than 3 kinds, so as not to increase the burden on the liver and the interaction between drugs.
1. Reduced glutathione + magnesium isoglycyrrhizinate
Transaminase such as ALT and AST can rapidly reduce liver damage in patients with blood diseases after chemotherapy.
2. Reduced glutathione + cell membrane protectant (such as polyene phosphatidylcholine)
It can protect the liver from different links and can be used for alcoholic liver disease (ALD).
3. Glycyrrhizic acid preparations + antioxidants (such as reduced glutathione)
In the various stages before and after the production of inflammatory factors, the combination can reduce the continuation of inflammatory factors and avoid the continued increase of liver damage. It can neutralize the inflammatory factors that have been produced and alleviate the liver damage that has been caused.