The Role of Losartan Potassium in the Treatment of Hypertension
Losartan potassium is the first clinical non-peptide angiotensin II receptor antagonist with high affinity for AT1 subtypes. It can selectively and competitively bind to AT1 receptor, thereby block the physiological effects of angiotensin II-mediated and achieve hypotensive effect. After the oxidation of losartan, the metabolites with pharmacological activity are produced by the liver oxidation. The half-life of losartan is longer than that of the prototype drug, which makes the antihypertensive effect stronger and more durable. And the action will last for 24 hours after taking the medicine once a day. In addition, the drug is very significant to prevent left ventricular remodeling after myocardial infarction, treat heart failure, reduce proteinuria, retard cerebral arteriosclerosis and stroke, postpon diabetic nephropathy, renal insufficiency, and diabetes complicated with cardiovascular disease. From this study, we can see that after using losartan potassium, the blood pressures of the two groups bave been better to some extent.
Experiments have shown that medication plus the intervention of lifestyle is more effective in the treatment of hypertension. In the treatment of hypertension, the cognitive level and coordination degree of the patient will have a great influence on the control of hypertension. Therefore, it is critical to help patients to establish a healthy lifestyle, which includs reasonable diet, weight control, reduction of salt intake, moderate exercise, no smoking or drinking and healthy psychology. All of these can obviously improve the effect of the treatment.