Antifungal drugs - mupirocin ointment
Antifungal drugs: fungal infection can be divided into two types - superficial fungal infections and deep fungus infection. Superficial infection is caused by tinea versicolor invading the body surface such as skin, hair, finger (toe) nail. Superficial infection with high incidence but less harmfulness. Deep fungal infection is caused by candida and Cryptococcus invading internal organs and deep tissues. Deep fungal infection with low incidence but more harmfulness. Only Fluconazole (Diflucan) and Flucytosine can pass through the blood-brain barrier to treat central fungal infections in all antifungal drugs.
Mupirocin ointment is a kind of antibiotics for local & external use, which is applied to wounded part. In clinical treatment, it is used for skin infection caused by gram-positive coccus especially staphylococcus and streptococcus. It is also effective for drug-resistant staphylococcus aureus and has certain effect on some negative bacteria. It is a kind of white hydrophilic ointment, and its main ingredient is mupirocin. It is used for primary skin infection such as impetigo, furuncle swollen, folliculitis and secondary skin infection such as eczema amalgamative infection, ulcer amalgamative infection and wound amalgamative infection.
Mupirocin ointment acts on isoleucine tRNA synthetase and isoleucine combining point in the bacteria body, which can block the synthesis of amino acids and exhaust tRNA in the cell at the same time and suspend the RNA and protein synthesis in the sensitive bacteria. The affinity of mupirocin ointment to mammalian isoleucine tRNA synthase is very low, so there is little toxicity to humans. Mupirocin has strong antibacterial activity against aerogram-positive cocci, especially staphylococcus aureus, staphylococcus epidermis and streptococcus suppurative about the skin infections. It is also effective against drug-resistant staphylococcus aureus.
The gram-negative bacteria which is sensitive to mupirocin ointment include haemophilus influenzae, gonorrhoeae, etc. This product has a weak inhibition on normal skin flora such as micrococcus, Corynebacterium and propionic acid, which play a role in the innate anti-infection barrier. It has no inhibitory effect on pseudomonas aeruginosa, anaerobic bacteria and fungi. Mupirocin ointment has no cross-resistance to other antibiotics. Compared with other commonly used antibiotics in dermatologic patients, mupirocin ointment remains sensitive to sensitive strains.