Antibacterial action of Mupirocin
Mupirocin has been launched for more than 20 years. With the unique antibacterial mechanism, it has quickly become the first choice for local antibacterial treatment in dermatology department, and its efficacy has been recognized by more and more doctors and patients.
Mupirocin with other English names: Bactroban; Mupirocinum; Bactroban Nasal; Pseudomonic acid; 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid.
CAS Number: 12650-69-0
Molecular formula: C26H44O9
Molecular weight: 500.62200
It was a bacterial metabolite isolated from fluorescence pseudomonas in 1971.
The main mechanism of mupirocin antibacterial action is to inhibit the protein synthesis of bacteria such as staphylococcus aureus. Mupirocin side chains on the three-dimensional structure is similar with isoleucine (Ile), which can be combined with isoleucine Ile tRNA synthesis parts in bacterial cells for competitive combination to form reversible complexes and prevent its further combination with Ile. And then exhausting tRNA contained Ile in the cell, which can affect or terminate protein synthesis in the bacterial body. Because of the different antibacterial mechanism between mupirocin and other antibiotics, there is no cross resistance between mupirocin and other antibiotics. Moreover, because of the low binding force between mupirocin and mammalian isoleucine tRNA synthase, there is less toxic to humans and animals. When it enters the human body, the half-life in the body is very short, and it will be decomposed into inactive monocytic acid quickly. In clinical practice, it is only used for local external use.
Vitro bacteriostatic experiment shows that there is higher antimicrobial activity mupirocin on Gram-positive bacteria such as staphylococcus aureus, epidermis staphylococcus and streptococcus pyogenes, higher sensitivity on multiple antibiotics staphylococcus aureus strains with drug resistance.
Selected from Advances in bacterial resistance to mupirocin