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Therapeutic Effect of Nicotinamide Mononucleotide on Vascular Disorders Therapeutic Effect of Nicotinamide Mononucleotide on Vascular Disorders

Another serious health-threatening disease associated with aging is Cardiovascular Disease (CVD), which has the characteristics of high incidence, high disability, and a wide range of hazards. This type of disease is mainly caused by the imbalance of the oxidation system and the antioxidant system after the body ages, and the accumulation of superoxide in the blood vessels causes oxidative damage to the body. Studies have found that supplementation with nicotinamide mononucleotide can reduce vascular oxidative stress and improve aortic sclerosis and vascular dysfunction. Supplementation of NMN can reduce collagen accumulation throughout the blood vessels, increase arterial elastin accumulation, reduce arteriosclerosis, and delay arterial aging that occurs with age. The CAS number of the NMN is 1094-61-7. NMN mainly restores the activity of Sirt1 in arteries by increasing NAD+ bioavailability in the vascular system, improving endothelial dysfunction caused by aging and large elastic arteriosclerosis. NMN can also reduce the accumulation of reactive oxygen species in cells by enhancing the metabolic flux of the Krebs cycle and the electron transport chain, and increase the level of NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) to maintain glutathione and thiol reduced protein antioxidant system. In addition, NMN can improve lipid distribution in plasma and maintain blood glucose levels, thereby improving vascular function.
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