Sinoway Industrial Co., Ltd.

Therapeutic Effect of Nicotinamide Mononucleotide on Type 2 Diabetes Mellitus Therapeutic Effect of Nicotinamide Mononucleotide on Type 2 Diabetes Mellitus

Chronic inflammation is an important factor in the islet beta cell failure in type 2 diabetes mellitus (T2DM). Exposure to pro-inflammatory cytokines such as interleukin 1β (IL1β) and Tumor necrosis factor α (TNFα) can cause islet β cell death and inhibit insulin secretion. Because the pancreas lacks iNAMPT (intracellular Nampt), islets rely on circulating eNAMPT (extracellular Nampt) to stimulate insulin secretion. Nicotinamide mononucleotide can restore eNampt levels, reverse the impaired insulin secretion, and protect the islets from the negative effects of pro-inflammatory factors. The CAS number of NMN is 1094-61-7.

Caton et al. found that NMN can improve islet dysfunction in high fructose (FRD) mice, reverse FRD and pro-inflammatory cytokine-mediated changes in islet marker gene expression, reduce pro-inflammatory factor expression, restore insulin secretion and improve cytokine Nampt-mediated islet dysfunction. Taken together, NMN improves islet function in FRD mice and is associated with beneficial changes in gene expression involved in glucose metabolism, anti-inflammatory and apoptotic processes.
Related News
  • TEL:+86-0592-5853819
  • FAX:+86-0592-5854960
  • EMAIL: xie@china-sinoway.com
  • ADDRESS:Floor 16, Huicheng Business Center, No. 839, Xiahe Rd., Siming Dist. Xiamen, Fujian, China
//