Sinoway Industrial Co., Ltd.

Pemetrexed Disodium 357166-30-4 Pemetrexed Disodium 357166-30-4

Pemetrexed Disodium 357166-30-4
Related Products
  • NanoActive alpha lipoic acid (ALA) 1077-28-7

    1.Basic information of NanoActive alpha lipoic acidProduct Name: NanoActive alpha lipoic acid (ALA)Other Names: NanoActive THIOOCTIC ACIDAppearance: yellow, viscous and transparent liquidTest Method: ...

  • NanoActive Astaxanthin 472-61-7

    1.Basic information of NanoActive AstaxanthinProduct Name: NanoActive AstaxanthinOther Names: NanoActive AstaAppearance: reddish to dark red, viscous and transparent liquidTest Method: HPLCCAS NO.: 47...

  • NanoActive Curcumin 458-37-7

    1.Basic information of NanoActive CurcuminProduct Name: NanoActive CurcuminOther Names: NanoActive turmeric extractAppearance: yellow, viscous and transparent liquidTest Method: HPLCCAS NO.: 458-37-7S...

Basic information of Pemetrexed disodium:

Name

Pemetrexed disodium

Alias

Pemetrexed disodium for Injection; Pemetrexed Disodium 2.5 hydrate; Pemetrexed Disodium7 hydrate

CAS NO.

357166-30-4

Molecular Formula

2(C20H19N5Na2O6).5(H2O)

Molecular Weight

1032.84

Grade Standard

Medicine grade  / 99% min

Package Size

1kg/bag 

Storage:

Keep in a well-closed container, protected from light and stored at a temperature of 2 to 8


Use of Pemetrexed disodium: 

Pemetrexed disodium is combined with cisplatin for the treatment of inoperable malignant pleural mesothelioma. 

Pemetrexed is an antifolate preparation whose structure contains a pyrrolizidine group, which inhibits cell growth by disrupting the normal metabolic process of folate-dependent cells and inhibiting cell replication. In vitro studies have shown that pemetrexed inhibits the activity of thymidylate synthase, dihydrofolate reductase, and glycinamide nucleotide formyltransferase, which are essential enzymes for the synthesis of folic acid and are involved in thymidine nucleus. Bioresynthesis of glycosides and purine nucleotides. Pemetrexed enters the cell by a carrier carrying folic acid and a folate-binding protein transport system on the cell membrane. Once pemetrexed enters the cell, it is converted to the form of polyglutamate by the action of folate polyglutamate synthetase. Polyglutamate remains in the cell and becomes an inhibitor of thymidylate synthase and glycinamide nucleotide formyltransferase. Polyglutamination exhibits a time-concentration-dependent process in tumor cells with a low concentration in normal tissues. The half-life of the polyglutamate metabolite in the tumor cells is prolonged, thereby prolonging the action time of the drug in the tumor cells.

Preclinical studies have shown that pemetrexed inhibits the growth of mesothelioma cell lines (MSTO-211H, NCI-H2052) in vitro. A study of the mesothelioma cell line MSTO-211H showed a synergistic effect of pemetrexed in combination with cisplatin 

COA of Pemetrexed disodium:

Test Items

Standard

Test Results

Character

Almost-white or light yellow unfixed powder, smell-less, hygroscopic freely.

white unfixed powder, smell-less, hygroscopic freely.

Solubility

Soluble in water very freely, hardly soluble in ethanol or chloroform or ethyl ether.

Conforms

PH

6.5-8.5

7.2

Clarity and color of solution

Meet the requirements.

Conforms

Related substance

Max single impurity≤0.1%

0.036%

Total impurity≤0.5%

0.17%

Heavy Metal

<20ppm

Conforms

Water

7.2%-10.2%

8.8%

Chloride

≤0.02%

Conforms

Ethanol

≤5000ppm

1687ppm

Dichloromethane

≤600ppm

Not Detected

N,N-Dimethylformamide

≤880ppm

Not Detected



  • Rivaroxaban 366789-02-8
    Basic information of Rivaroxaban :NameRivaroxabanAlias(S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({... Rivaroxaban 366789-02-8
  • Orlistat 96829-58-2
    Basic information of OrlistatNameOrlistatCAS96829-58-2EINECSMolecular FormulaC29H53NO5Molecular Weight495.73Quality Standard USP37/ in-house standarad, 98.5%Package Size5kg/tinBrief IntroductionWhite ... Orlistat 96829-58-2
  • Galantamine 357-70-0
    Basic information of GalantamineNameGalantamineAliasGalantamine hydrobromCAS Number357-70-0Molecular FormulaC17H21NO3Molecular Weight287.35Quality StandardIn housePackage Size5kg/bag, 10kg/bag, accord... Galantamine 357-70-0
  • Amphotericin B 1397-89-3
    Basic information of Amphotericin BNameAmphotericin B Alias Fungizone;Amphotericin B injectable grade non sterileCAS NO.1397-89-3Molecular Formula C47H73NO17Molecular Weight 924.07902Quality Standard... Amphotericin B 1397-89-3

MORE_DETAIL Pemetrexed Disodium 357166-30-4

Basic information of Pemetrexed disodium:

Name

Pemetrexed disodium

Alias

Pemetrexed disodium for Injection; Pemetrexed Disodium 2.5 hydrate; Pemetrexed Disodium7 hydrate

CAS NO.

357166-30-4

Molecular Formula

2(C20H19N5Na2O6).5(H2O)

Molecular Weight

1032.84

Grade Standard

Medicine grade  / 99% min

Package Size

1kg/bag 

Storage:

Keep in a well-closed container, protected from light and stored at a temperature of 2 to 8


Use of Pemetrexed disodium: 

Pemetrexed disodium is combined with cisplatin for the treatment of inoperable malignant pleural mesothelioma. 

Pemetrexed is an antifolate preparation whose structure contains a pyrrolizidine group, which inhibits cell growth by disrupting the normal metabolic process of folate-dependent cells and inhibiting cell replication. In vitro studies have shown that pemetrexed inhibits the activity of thymidylate synthase, dihydrofolate reductase, and glycinamide nucleotide formyltransferase, which are essential enzymes for the synthesis of folic acid and are involved in thymidine nucleus. Bioresynthesis of glycosides and purine nucleotides. Pemetrexed enters the cell by a carrier carrying folic acid and a folate-binding protein transport system on the cell membrane. Once pemetrexed enters the cell, it is converted to the form of polyglutamate by the action of folate polyglutamate synthetase. Polyglutamate remains in the cell and becomes an inhibitor of thymidylate synthase and glycinamide nucleotide formyltransferase. Polyglutamination exhibits a time-concentration-dependent process in tumor cells with a low concentration in normal tissues. The half-life of the polyglutamate metabolite in the tumor cells is prolonged, thereby prolonging the action time of the drug in the tumor cells.

Preclinical studies have shown that pemetrexed inhibits the growth of mesothelioma cell lines (MSTO-211H, NCI-H2052) in vitro. A study of the mesothelioma cell line MSTO-211H showed a synergistic effect of pemetrexed in combination with cisplatin 

COA of Pemetrexed disodium:

Test Items

Standard

Test Results

Character

Almost-white or light yellow unfixed powder, smell-less, hygroscopic freely.

white unfixed powder, smell-less, hygroscopic freely.

Solubility

Soluble in water very freely, hardly soluble in ethanol or chloroform or ethyl ether.

Conforms

PH

6.5-8.5

7.2

Clarity and color of solution

Meet the requirements.

Conforms

Related substance

Max single impurity≤0.1%

0.036%

Total impurity≤0.5%

0.17%

Heavy Metal

<20ppm

Conforms

Water

7.2%-10.2%

8.8%

Chloride

≤0.02%

Conforms

Ethanol

≤5000ppm

1687ppm

Dichloromethane

≤600ppm

Not Detected

N,N-Dimethylformamide

≤880ppm

Not Detected


Leave a Message Email Us

We will contact you within 24 hours.

  • TEL:+86-0592-5853819
  • FAX:+86-0592-5854960
  • EMAIL: xie@china-sinoway.com
  • ADDRESS:Floor 16, Huicheng Business Center, No. 839, Xiahe Rd., Siming Dist. Xiamen, Fujian, China