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Ketoconazole 65277-42-1 Ketoconazole 65277-42-1

Ketoconazole 65277-42-1
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Basic information of  Ketoconazole

Name

Ketoconazole

Alias

 fungoral; Onofin K; nizoral; ketoderm; fungarest;
1-[4-(4[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

CAS NO.

65277-42-1

Molecular Formula

C26H28Cl2N4O4

Molecular Weight

531.43

Quality Standard

USP

Grade Standard

Medicine grade  / UN2811 Class 6.1, PGIII

Package Size

25kg/drum

Use of Ketoconazole

Ketoconazole is an imidazole antifungal agent, and its mechanism of action is to inhibit the biosynthesis of the fungal cell membrane ergosterol, affecting the permeability of the cell membrane and inhibiting its growth. Ketoconazole can be used to treat superficial and deep mycosis, such as skin and nail files, vaginal candidiasis, gastrointestinal fungal infections, etc., as well as whole body caused by Candida albicans, coccidioides, histoplasma, infection , etc.

COA of Ketoconazole

Items


Standard 

Identification

 IR

Melting range

148°C ~ 152°C

Specific  rotation

-1º~ +1º

Loss on drying

≤0.5%

Residue on ignition

≤0.1%

Heavy metals

≤0.002%

Chromatographic purity

≤2.0%

Residual solvents

acetone≤0.5% 

acetoacetate≤0.5% 

dimethyl sulfoxide≤0.5%

Assay

98.0%~102.0%

Conclusion              

The product complies to the standard of  USP32.



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MORE_DETAIL Ketoconazole 65277-42-1

Basic information of  Ketoconazole

Name

Ketoconazole

Alias

 fungoral; Onofin K; nizoral; ketoderm; fungarest;
1-[4-(4[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

CAS NO.

65277-42-1

Molecular Formula

C26H28Cl2N4O4

Molecular Weight

531.43

Quality Standard

USP

Grade Standard

Medicine grade  / UN2811 Class 6.1, PGIII

Package Size

25kg/drum

Use of Ketoconazole

Ketoconazole is an imidazole antifungal agent, and its mechanism of action is to inhibit the biosynthesis of the fungal cell membrane ergosterol, affecting the permeability of the cell membrane and inhibiting its growth. Ketoconazole can be used to treat superficial and deep mycosis, such as skin and nail files, vaginal candidiasis, gastrointestinal fungal infections, etc., as well as whole body caused by Candida albicans, coccidioides, histoplasma, infection , etc.

COA of Ketoconazole

Items


Standard 

Identification

 IR

Melting range

148°C ~ 152°C

Specific  rotation

-1º~ +1º

Loss on drying

≤0.5%

Residue on ignition

≤0.1%

Heavy metals

≤0.002%

Chromatographic purity

≤2.0%

Residual solvents

acetone≤0.5% 

acetoacetate≤0.5% 

dimethyl sulfoxide≤0.5%

Assay

98.0%~102.0%

Conclusion              

The product complies to the standard of  USP32.


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