Sinoway Industrial Co., Ltd.

NMN Helps Maintain Telomere Length and Improve Liver Fibrosis NMN Helps Maintain Telomere Length and Improve Liver Fibrosis

Telomeres are the repetitive ends of chromosomes and consist of double-stranded TTAGGG repeats that play an important role in maintaining genetic information stability. Telomerase and telomere length have been shown to affect human disease and aging.

A team from Hisayuki Amano of Baylor College of Medicine in the United States discovered the link between telomeres and Sirtuins and demonstrated the potential of nicotinamide mononucleotide to improve telomere-related diseases such as liver fibrosis through animal experiments. The CAS number of nicotinamide mononucleotide is 1094-61-7. The latest developments in this study were published on the March 28, 2019, Cell Metabolism.
Cell Metabolism
To determine the association between elevated levels of NAD+ and telomere-mediated diseases, the investigators tested whether NMN could improve telomere-dependent liver fibrosis. This is a disease caused by telomere dysfunction (hereditary telomerase mutation). The experimental mice were given NMN continuously for 2 weeks, followed by injection of the fibrosis inducer CCl4 (12 injections twice a week). NMN was then continued for 6 consecutive weeks. The experimental results confirmed that G4 mice with telomere dysfunction were more susceptible to DNA damage than wild-type WT mice, and NMN significantly improved liver damage and liver fibrosis of G4 mice. In addition, it is worth mentioning that NMN also improved its fibrosis in wild-type WT mice. This indicates that the NMN supplement has the effect of protecting the DNA from damage, regardless of whether the telomere is damaged.
Related News
  • TEL:+86-0592-5853819
  • FAX:+86-0592-5854960
  • EMAIL: xie@china-sinoway.com
  • ADDRESS:Floor 16, Huicheng Business Center, No. 839, Xiahe Rd., Siming Dist. Xiamen, Fujian, China
//