Telomeres are the repetitive ends of chromosomes and consist of double-stranded TTAGGG repeats that play an important role in maintaining genetic information stability. Telomerase and telomere length have been shown to affect human disease and aging.
A team from Hisayuki Amano of Baylor College of Medicine in the United States discovered the link between telomeres and Sirtuins and demonstrated the potential of nicotinamide mononucleotide
to improve telomere-related diseases such as liver fibrosis through animal experiments. The CAS number of nicotinamide mononucleotide is 1094-61-7. The latest developments in this study were published on the March 28, 2019, Cell Metabolism.
To determine the association between elevated levels of NAD+ and telomere-mediated diseases, the investigators tested whether NMN
could improve telomere-dependent liver fibrosis. This is a disease caused by telomere dysfunction (hereditary telomerase mutation). The experimental mice were given NMN continuously for 2 weeks, followed by injection of the fibrosis inducer CCl4 (12 injections twice a week). NMN was then continued for 6 consecutive weeks. The experimental results confirmed that G4 mice with telomere dysfunction were more susceptible to DNA damage than wild-type WT mice, and NMN significantly improved liver damage and liver fibrosis of G4 mice. In addition, it is worth mentioning that NMN also improved its fibrosis in wild-type WT mice. This indicates that the NMN supplement has the effect of protecting the DNA from damage, regardless of whether the telomere is damaged.