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β-nicotinamide Mononucleotide, Nmn Promotes Angiogenesis and Increase Exercise Ability β-nicotinamide Mononucleotide, Nmn Promotes Angiogenesis and Increase Exercise Ability

NAD + is a conservative molecule that exists in many kinds of organisms. It decreases with age and has been shown to stimulate SIRT 1 activation. Abhirup Das, a postdoctoral researcher at Sinclair Laboratory, said: "We hypothesize that a decrease in NAD + levels may reduce the activity of SIRT-1, thereby affecting angiogenesis in aging mice."

To test this hypothesis, scientists have used the precursor of compound NMN - NAD plays an important role in repairing cell DNA and maintaining cell viability. In cell experiments, the growth ability of human and mouse endothelial cells was enhanced and the cell death rate was reduced after NMN treatment. In animal experiments, the researchers injected NMN into a group of 20-month-old mice(roughly 70 years old in human years). NMN treatment can restore the capillary number and density to normal in young mice. Muscle blood flow also increases significantly, and the blood supply of muscle is significantly higher than that of non-NMN-treated mice of the same age.

Most notably, it enhanced the motor ability of aging mice. The results showed that compared with untreated mice, the exercise ability of treated mice increased by 56%-80%. NMN treated mice ran 430 meters on average, about 1400 feet, while untreated mice ran only 240 meters, about 780 feet. To further enhance the role of NMN, the researchers added a second compound, NaHS, which is a precursor of hydrogen sulfide and also enhances the activity of SIRT 1. A group of 32-month-old mice, about 90 years of age equivalent to human years, ran twice as far as untreated mice after four weeks of comprehensive treatment. In contrast, the average running distance of mice treated with NMN alone was 1.6 times that of untreated mice.

The results of this study are expected for millions of elderly people, for whom regular physical exercise is unrealistic. The team's goal is to repeat this experiment and eventually develop a small molecule drug based on NMN that mimics motor function and increases blood and oxygen supply to muscles and tissues. It may even help to regenerate the blood vessels of organs. Ischemia and hypoxia are common causes of heart disease and ischemic stroke.
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