As the saying goes, vessel age reflects real age. So can reversing vascular aging restore youthful vitality? The answer seems to be yes. Researchers at Harvard Medical School have confirmed the key cellular mechanisms underlying vascular aging and its effects on muscle health, and have successfully reversed this biological process. Relevant results were published in Cell Journal on March 2, 2018. The study found barriers to normal interaction between muscles and blood vessels that maintain the health of both tissues.
Scientists took advantage of precursor NMN
from two molecules in vivo. Vessel atrophy and muscle atrophy in aging mice were reversed successfully, and their exercise endurance was enhanced. The team claims that the results pave the way for the development of human-related therapies. David Sinclair, professor of genetics and deputy director of Paul F. Glenn Center for Aging Biology, Harvard Medical School, said: "We have found a way to reverse vascular aging by increasing the presence of molecules (NMN) in the body, thereby enhancing exercise endurance." Professor Snapair of the School of Medicine, University of New South Wales, Sydney, Australia, added: "This method promotes vascular growth and increases vascular endurance, thereby enhancing the endurance of mice and laying the foundation for the cure of diseases caused by vascular aging in humans." Researchers caution that because of significant biological differences, many promising treatments in mice have not had the same effect on humans. However, the results of this study are sufficient to support human trials. And Sinclair says clinical safety trials are already under way.