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Dexamethasone 50-05-2

Dexamethasone 50-05-2

99% up by HPLC, USP38/BP2010/EP6
  • Product Details

Product Information


Product name

Dexamethasone

CAS No.

50-05-2

Molecular Formula

C22H29FO5

Molecular Weight

392.461

Quality Standard

99% up by HPLC, USP38/BP2010/EP6

Appearance

White powder


COA of Dexamethasone


Items

Specifications

Results

 

Character

White to almost white crystalline powder

Almost white crystalline powder

 

Specific rotation

+72°to +80°

+76.7°

 

Identification

 

Complies by IR

Conforms

 

Complies by UV 3.0%

0.7%

 

Test

 

Chromatographic Purty

Principal impurity not more than 1.0%

0.07%

 

Total impurities not more than 2.0%

0.36%

 

Loss on drying

Not more than 0.5%

0.1%

 

Residue Solvent

Not more than 0.2%

0.07%

 

Chloroform

Not more than 60ppm

Undetected

 

Methanol

Not more than 1000ppm

210ppm

 

Ethyl Acetate

Not more than 300ppm

14ppm

 

Assay

Contains 97.0% to 102.0% of C22H29FO5 Calculated on dried basis

99.5%

 

Conclusion

The goods conforms to USP38

 

 

Usage


Function of Dexamethasone

Dexamethasone, also known as flumethasone, flumethasone. Dexamethasone is a glucocorticoid. Its derivatives include hydrocortisone, prednisone, etc., and its pharmacological effects are mainly anti-inflammatory, anti-toxic, anti-allergic, and anti-rheumatic, and are widely used in clinical practice.


1. Anti-inflammatory effect: It can reduce and prevent the tissue's response to inflammation, thereby reducing the performance of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and white blood cells, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators.


2. Immunosuppressive effects: including preventing or suppressing cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, and reducing the ability of immunoglobulin to bind to cell surface receptors , And inhibit the synthesis and release of interleukins, thereby reducing the transformation of T lymphocytes into lymphoblasts, and reducing the expansion of the primary immune response. It can reduce the passage of immune complexes through the basement membrane, and can reduce the concentration of complement components and immunoglobulins.


Dexamethasone is easily absorbed from the digestive tract. The plasma T1/2 is 190 minutes, and the tissue T1/2 is 3 days. After intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate, it reaches the blood within 1 hour and 8 hours, respectively. Peak drug concentration. The binding rate of dexamethasone to plasma protein is lower than that of other corticosteroids. Its anti-inflammatory activity of 0.75 mg is equivalent to 5 mg of prednisolone. In addition, as an adrenal cortex hormone drug, dexamethasone has stronger anti-inflammatory, anti-allergic and anti-toxic effects than prednisone, and has very light water and sodium retention and promotion of potassium excretion. It can be injected intramuscularly or intravenously on the pituitary and adrenal glands. Strong inhibitory effect.

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