Recently, Peng Liang and Xie Wei's research team at the Third Affiliated Hospital of Sun Yat-sen University discussed the role of nicotinamide mononucleotide
whose CAS number is 1094-61-7 in the treatment of age-related diseases by regulating mesenchymal stem cells (MSCs). Their research was published in the journal Cell Death & Diease.
Mesenchymal stem cells (MSCs) are adult stem cells with self-replication ability and multi-directional differentiation potential, which can differentiate into mature cells such as osteoblasts, chondrocytes and fat cells. However, existing MSC culture methods limit the potential for MSC self-renewal, resulting in unsatisfactory treatment outcomes.
Chinese scientists have studied whether NMN
has an effect on the expansion and differentiation of mouse mesenchymal stem cells (MSC) in vitro and in vivo.
In vitro experiments showed that compared with the control group (0.30±0.021%), NMN significantly promoted the expansion of MSCs in vitro and in vivo, thus avoiding various defects in vitro culture and reducing long-term subculture.