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Nicotinamide Adenine Dinucleotide and its Application Nicotinamide Adenine Dinucleotide and its Application

Nicotinamide adenine dinucleotide(NAD or NAD +, for short), once known as pyridine diphosphate nucleotide (DPN) or coenzyme I or oxidized coenzyme I. It's a coenzyme that transports electrons (or, more accurately, hydrogen ions) and appears in many cellular metabolic reactions. NADH (perhaps NADH + H + is more accurate) is its reduction form.


NAD is involved in many physiological activities, such as cell metabolism, energy synthesis, cell DNA repair, and plays an important role in the immune capacity of the body. In a healthy state, the concentration of NAD in the human body is stable, maintaining the normal function of various cells. The concentration of nicotinamide adenine dinucleotide in vivo determines the process and degree of cell ageing, and the decrease of the concentration will accelerate the process of cell ageing. As a result, nad gradually gained public recognition and began to be widely used in the field of anti-ageing dietary supplements/health products.


In addition, modern pharmacological experiments show that nad can significantly increase the foot contraction threshold of ICR mice after inoculating 4T1 mice breast cancer cells in the marrow cavity, which has an analgesic effect, suggesting that nad can be used to treat cancer pain. In another pharmacological experiment, ICR mice injected with nad had an analgesic effect on inflammatory pain induced by formalin or complete Freund's adjuvant, suggesting that nad can be used to treat inflammatory pain.


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