Losartan in the Treatment of Essential Hypertension Complicated with Left ventricular Hypertrophy
Essential hypertension complicated with left ventricular hypertrophy is a serious and perilous disease in the cardiovascular medicine. It is one of the main causes of heart failure and myocardial infarction. So, in the treatment, first of all, we should try to control the blood pressure and make it in the normal range, so as not to increase the burden of the heart, and to reverse the hypertrophy of the left ventricle to make the heart shoot blood. And we should reverse the hypertrophic left ventricle so that the ejection ability of the heart will not be affected. The losartan is a kind of statins, and it is a highly selective vascular tension inhibitor, which has obvious effect on vascular tension and spasm. It can control the activity of myocardial cells, eliminate the inflammatory mediators that may cause the myocardium, eliminate the free radicals on the wall of the cardiac myocytes, restore the function of the endothelial cells, and restore the fibrosis of the interstitial cells of the myocardium. The results showed that the effective rate of losartan treatment was 84.6%, and the left ventricular ejection fraction increased after treatment. The value of the left ventricular end-diastolic dimension, the IVST of the end-diastole, the thickness of posterior left ventricle, the left ventricular weight were significantly reduced. It indicated that losartan is effective in the treatment of left ventricular hypertrophy. In the treatment of primary hypertension with left ventricular hypertrophy, losartan can be added to the basic treatment to improve the symptoms and stop the left ventricle to continue to thickening. The curative effect is remarkable and it is trustworthy. The losartan potassium is also an effective drug.