Injection Grade Amphotericin B
Injection grade Amphotericin B, the product is suitable for sensitive fungi caused by deep fungal infection and the progressive progression of the disease, such as sepsis, endocarditis, meningitis (cryptococcal and other fungi), abdominal infection (including with Dialysis stakeholders), lung infections, urinary tract infections and endophthalmitis.
Intravenous drug: start intravenous infusion of 1 ~ 5mg or 0.02 ~ 0.1mg / kg once a body weight, then according to patient tolerance daily or every other day to increase 5mg, when increased to a 0.6 ~ 0.7mg / kg When you can temporarily increase the dose, this is the general treatment volume. The maximum daily dose of adult does not exceed 1mg / kg, daily or every 1 to 2 days to administer 1, the cumulative total 1.5 ~ 3.0g, course of 1 to 3 months, can also be as long as 6 months, depending on the condition and Depending on the type of disease. Sensitive fungal infection should adopt a smaller dose, that adult once 20 ~ 30mg, treatment should be long.
Intrathecal administration: the first 0.05 ~ 0.1mg, later increased to 0.5mg each, the maximum amount of not more than 1mg, administered 2 to 3 times a week, the total amount of about 15mg. Intrathecal administration of low-dose dexamethasone or hydrocortisone succinate should be given at the same time, and the need to repeatedly dilute the solution with cerebrospinal fluid, while slowly adding diluted to reduce the adverse reactions.
Topical use: Aerosol inhalation of adults each time 5 ~ 10mg, with sterile water for injection dissolved into 0.2% ~ 0.3% solution application; ultrasonic atomization inhalation concentration of 0.01% to 0.02%, daily inhalation of 2 to 3 Times, each inhalation 5 ~ 10ml; continuous bladder irrigation daily amphotericin B 5mg added 1000ml sterile water for injection, according to the injection rate of 40ml per hour for flushing, sharing 5 to 10 days.
Intravenous or intrathecal administration, the first 10ml of sterile water for injection preparation of this product 50mg, or 5ml formulated 25mg, and then diluted with 5% glucose injection (not available sodium chloride injection, due to precipitation) , The drug concentration of the infusion solution does not exceed 10mg / 100ml, slow intravenous infusion of light, each infusion time of 6 hours or more, the dilution of glucose injection pH value should be 4.2 or more.
Intrathecal injection may take the concentration of 5mg / ml solution 1ml, add 5% glucose injection 19ml diluted to a final concentration of 250μg / ml. Take the amount of liquid injection required to repeatedly dilute the cerebrospinal fluid 5 ~ 30ml, and slowly injected. Intrathecal injection of drug concentration can not be higher than 25mg / 100ml, pH value should be 4.2 above.