Recently, Jinan City, Shandong Normal University Hospital Community Health Service Station researchers published a paper designed to explore the valsartan
and hydrochlorothiazide or indapamide combination of young and middle-aged patients with mild to moderate hypertension. Studies have shown that valsartan, valsartan and hydrochlorothiazide or indapamide combination can effectively reduce middle-aged and high-blood pressure, valsartan and hydrochlorothiazide group or indapamide combination group was significantly better than valsartan Single-use group, the safety of each group is better, the compound preparation group medication compliance better. The article was published in the 2016 issue of 10 "Chinese community physicians" magazine.
Randomized, single-blind, parallel control method, 72 cases of young and middle-aged hypertensive patients were randomly divided into 3 groups, 24 cases in each group. Valsartan group: valsartan alone 80 ~ 160 mg, 1 / d; valsartan and hydrochlorothiazide combination group: valsartan 80 mg hydrochlorothiazide 12.5 mg, 1 / d; valsartan and indapamide Amine combination group: valsartan 80 mg plus indapamide 1.25 mg, 1 / d, for 8 weeks, before and after treatment to observe changes in blood pressure, medication safety, compliance.
Valsartan and hydrochlorothiazide or indapamide combination group, the total effective rate of lowering blood pressure and blood pressure were significantly better than valsartan alone group (P <0.01). No significant adverse reactions were observed in the three groups. The compliance of the compound preparation group was better than that of the single drug combination group. The difference between the two groups was statistically significant (P <0.05).