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Paclitaxel 33069-62-4 Paclitaxel 33069-62-4

Paclitaxel 33069-62-4
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Basic information of Paclitaxel 33069-62-4

Name

Paclitaxel

Alias

N-BENZYL-BETA-PHENYLISOSERINE ESTER;PACLITAXEL,
TAXUS BREVIFOLIA;PACLITAXEL, TAXUS SPECIES; PACLITAXOL;
PACLITAXEL; TAXOL(TM);taxol a;TAXOL EQUIVALENT

CAS NO.

33069-62-4

Molecular Formula

C47H51NO14

Molecular Weight

853.91

Quality Standard

USP34

Package Size

1g/bag, 25kg/drum or per customer

As dangerous goods

UN1544,Class 6.1,PGIII


Use of Paclitaxel 33069-62-4

  • An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

COA of Paclitaxel 33069-62-4

Appearance

White or almost white crystalline powder

Identification

FT-IR

HPLC

NMR

Mass

Solubility

Soluble in ethanol, methanol, Chloroform, hardly soluble in water

Specific Optical Rotation

-49.0º ~ -55.0º at 20°C

Melting Point

213°C—216°C

Water

≤1.0%

Residual Solvent

Meets the requirements of ICH

Ethyl Acetate

≤5000ppm

Acetone

≤5000ppm

Methanol

≤3000ppm

Acetic acid

≤5000ppm

Residual of volatile Solvents

Meets the requirements of ICH

Chloroform

≤60ppm

Dichloromethane

≤600ppm

Hexane

≤290ppm

Toluene

≤890ppm

Residue on Ignition

≤0.2%

Bacteria endotoxins

≤0.4 USP EU/mg

Total aerobic microbial count

≤100 cfu/g

Staphylococcus aureus

Absence

Pseudomonas aeruginosa

Absence

Salmonella species

Absence

Escherichia Coli

Absence

Heavy Metals

≤20 ppm


IMPURITIES:

10-Deacetyl Baccatin III

≤0.1%

Baccatin III

≤0.2%

Photodegradant

≤0.1%

10-Deacetyl Paclitaxel

≤0.5%

2-Debenzoylpaclitaxel-2-pentenoate

≤0.7%

Oxetane ring opened, Acetyl and benzoyl

≤0.1%

10-Acetoacetyl paclitaxel

≤0.1%

10-Deacetyl-7-epi-paclitaxel

≤0.3%

7-epi-paclitaxel

≤0.4%

7-epi-paclitaxel

≤0.4%

10,13-Bissidechainpaclitaxel

≤0.5%

7-Acetyl Paclitaxel

≤0.6%



MORE_DETAIL Paclitaxel 33069-62-4

Basic information of Paclitaxel 33069-62-4

Name

Paclitaxel

Alias

N-BENZYL-BETA-PHENYLISOSERINE ESTER;PACLITAXEL,
TAXUS BREVIFOLIA;PACLITAXEL, TAXUS SPECIES; PACLITAXOL;
PACLITAXEL; TAXOL(TM);taxol a;TAXOL EQUIVALENT

CAS NO.

33069-62-4

Molecular Formula

C47H51NO14

Molecular Weight

853.91

Quality Standard

USP34

Package Size

1g/bag, 25kg/drum or per customer

As dangerous goods

UN1544,Class 6.1,PGIII


Use of Paclitaxel 33069-62-4

  • An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

COA of Paclitaxel 33069-62-4

Appearance

White or almost white crystalline powder

Identification

FT-IR

HPLC

NMR

Mass

Solubility

Soluble in ethanol, methanol, Chloroform, hardly soluble in water

Specific Optical Rotation

-49.0º ~ -55.0º at 20°C

Melting Point

213°C—216°C

Water

≤1.0%

Residual Solvent

Meets the requirements of ICH

Ethyl Acetate

≤5000ppm

Acetone

≤5000ppm

Methanol

≤3000ppm

Acetic acid

≤5000ppm

Residual of volatile Solvents

Meets the requirements of ICH

Chloroform

≤60ppm

Dichloromethane

≤600ppm

Hexane

≤290ppm

Toluene

≤890ppm

Residue on Ignition

≤0.2%

Bacteria endotoxins

≤0.4 USP EU/mg

Total aerobic microbial count

≤100 cfu/g

Staphylococcus aureus

Absence

Pseudomonas aeruginosa

Absence

Salmonella species

Absence

Escherichia Coli

Absence

Heavy Metals

≤20 ppm


IMPURITIES:

10-Deacetyl Baccatin III

≤0.1%

Baccatin III

≤0.2%

Photodegradant

≤0.1%

10-Deacetyl Paclitaxel

≤0.5%

2-Debenzoylpaclitaxel-2-pentenoate

≤0.7%

Oxetane ring opened, Acetyl and benzoyl

≤0.1%

10-Acetoacetyl paclitaxel

≤0.1%

10-Deacetyl-7-epi-paclitaxel

≤0.3%

7-epi-paclitaxel

≤0.4%

7-epi-paclitaxel

≤0.4%

10,13-Bissidechainpaclitaxel

≤0.5%

7-Acetyl Paclitaxel

≤0.6%


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