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Letrozole 112809-51-5 Letrozole 112809-51-5

Letrozole 112809-51-5
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Basic information of Letrozole

Name

Letrozole

Alias

4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;
FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;
Letrozole99%;CGS-20267, Femara

CAS NO.

112809-51-5

Molecular Formula

C17H11N5

Molecular Weight

285.3

Quality Standard

USP32

Package Size

25kg/drum

Use of Letrozole

  • A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic

COA of Letrozole

Items

Specification

Appearance

White to yellowish, crystalline powder

Identification

A.IR spectrum of sample should be identical to that of Reference Standard;

The retention time of major peak in the chromatogram of the Assay preparation
should correspond to that in the chromatogram of Standard preparation, as obtained in the Assay.

Showing the white precipitate reaction.

Water

Not more than 0.3%

Residue on Ignition

Not more than 0.1%

Heavy Metals

Not more than 0.001%


Related Compounds

Compound A: Not more than 0.1%

4,4’,4”-methylidenetrisbenzonitrile: Not more than 0.2%

Any other impurity: Not more than 0.1%

All other impurities: Not more than 0.3%

Residual Sovents

Ethanol: Not more than 3000ppm

Ethyl acetate: Not more than 2000ppm

DMF: Not more than 880ppm

Microbe Limit

Bacteria: Not more than 200/g

Mold and yeast: Not more than 50/g

Escherichia coli: should be absent

Assay(anhydrous)

98.0% to 102.0% of Cl7H11N5 on dried basis

Packaging and Storage

Preserve in tight containers at controlled room temperature.

Conclusion

Conforms to the USP32.



MORE_DETAIL Letrozole 112809-51-5

Basic information of Letrozole

Name

Letrozole

Alias

4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;
FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;
Letrozole99%;CGS-20267, Femara

CAS NO.

112809-51-5

Molecular Formula

C17H11N5

Molecular Weight

285.3

Quality Standard

USP32

Package Size

25kg/drum

Use of Letrozole

  • A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic

COA of Letrozole

Items

Specification

Appearance

White to yellowish, crystalline powder

Identification

A.IR spectrum of sample should be identical to that of Reference Standard;

The retention time of major peak in the chromatogram of the Assay preparation
should correspond to that in the chromatogram of Standard preparation, as obtained in the Assay.

Showing the white precipitate reaction.

Water

Not more than 0.3%

Residue on Ignition

Not more than 0.1%

Heavy Metals

Not more than 0.001%


Related Compounds

Compound A: Not more than 0.1%

4,4’,4”-methylidenetrisbenzonitrile: Not more than 0.2%

Any other impurity: Not more than 0.1%

All other impurities: Not more than 0.3%

Residual Sovents

Ethanol: Not more than 3000ppm

Ethyl acetate: Not more than 2000ppm

DMF: Not more than 880ppm

Microbe Limit

Bacteria: Not more than 200/g

Mold and yeast: Not more than 50/g

Escherichia coli: should be absent

Assay(anhydrous)

98.0% to 102.0% of Cl7H11N5 on dried basis

Packaging and Storage

Preserve in tight containers at controlled room temperature.

Conclusion

Conforms to the USP32.


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