Sinoway Industrial Co., Ltd.

Glatiramer Acetate 147245-92-9 Glatiramer Acetate 147245-92-9

Basic information of  Glatiramer acetate :

Name

Glatiramer acetate

Alias

L-GLUTAMICACIDPOLYMERWITHL-ALANINE,L-LYSINEANDL-TYROSINE,ACETATE(SALT);

CAS NO.

147245-92-9

Molecular Formula

C25H45N5O13

Molecular Weight

623.65

Brief Introduction

Glatiramer acetate is mainly used for multiple sclerosis



Use of  Glatiramer acetate: 

Glatiramer acetate is a synthetic peptide preparation consisting of four amino acids: glutamic acid, alanine, tyrosine and lysine. Copaxone was approved by the U.S. FDA in 1996 for the treatment of multiple sclerosis. In western countries with more patients with multiple sclerosis, the efficacy and tolerability of Copaxone have been fully affirmed.


COA of Glatiramer acetate :

   Tests

  Specifications

Results

Appearance

A white to slightly yellowish lyophilized materials

Meet the requirement

Solubility

Soluble in water and practically insoluble in acetone

Meet the requirement

Acetate content

(on anhydrous basis)

9.5%-12.0%

10.20%

Average molecular weight by gel filtration chromatography(Dalton)

4.7≤Mw≤11KDa

7409

Amino Acid Analysis

(Molar Fraction by HPLC)

L-Alanine: 3.50-5.50

L-Lysine: 2.50-4.50

L-Glutamic acid: 1.20-1.80

L-Tyrosine: 1.00

5.3

4.4

1.7

1.0

Water content(%w/w)

<5%

1.88%

Assay by HPLC(%w/w)

On Anhydrous basis

97.0-105.0%

104.81%

Bacterial endotoxin test

≤6.0EU/mg

Conforms


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