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Bortezomib Intermediates Bortezomib Intermediates

Bortezomib Intermediates
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Basic Information of Bortezomib Intermediates

  • CAS No. of key intermediates:179324-87-9
  • Other Names: (R)-BoroLeu-(+)-Pinanediol-CF3COOH
  • MF: C15H28BNO2.C2HF3O2
  • Purity:99.0%min
  • Appearance: White crystalline powder, White crystalline powder
  • Item:cas no.179324-87-9 & other Bortezomib intermediates
  • Shelf life: 2 years

Usage of Bortezomib Intermediates

  • As intermediate of Bortezomib.
  • Bortezomib  is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.
  • Bortezomib is associated with peripheral neuropathy in 30% of patients; occasionally, it can be painful. This can be worse in patients with pre-existing neuropathy. In addition, myelosuppression causing neutropenia and thrombocytopenia can also occur and be dose-limiting. However, these side effects are usually mild relative to bone marrow transplantation and other treatment options for patients with advanced disease. Bortezomib is associated with a high rate of shingles, although prophylactic acyclovir can reduce the risk of this. Acute interstitial nephritis has also been reported.
  • Gastro-intestinal (GI) effects and asthenia are the most common adverse events.

COA of Bortezomib Intermediates

(R)-Boroleu-(+)-pinanediolCF3COOH

Product name

(R)-Boroleu-(+)-pinanediolCF3COOH

CAS No.

179324-87-9

Molecular weight

379.23

Molecular Formula

C15H28BNO2.C2HF3O2

Appearance

white crystalline powder

Assay

99%min.


MORE_DETAIL Bortezomib Intermediates

Basic Information of Bortezomib Intermediates

  • CAS No. of key intermediates:179324-87-9
  • Other Names: (R)-BoroLeu-(+)-Pinanediol-CF3COOH
  • MF: C15H28BNO2.C2HF3O2
  • Purity:99.0%min
  • Appearance: White crystalline powder, White crystalline powder
  • Item:cas no.179324-87-9 & other Bortezomib intermediates
  • Shelf life: 2 years

Usage of Bortezomib Intermediates

  • As intermediate of Bortezomib.
  • Bortezomib  is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.
  • Bortezomib is associated with peripheral neuropathy in 30% of patients; occasionally, it can be painful. This can be worse in patients with pre-existing neuropathy. In addition, myelosuppression causing neutropenia and thrombocytopenia can also occur and be dose-limiting. However, these side effects are usually mild relative to bone marrow transplantation and other treatment options for patients with advanced disease. Bortezomib is associated with a high rate of shingles, although prophylactic acyclovir can reduce the risk of this. Acute interstitial nephritis has also been reported.
  • Gastro-intestinal (GI) effects and asthenia are the most common adverse events.

COA of Bortezomib Intermediates

(R)-Boroleu-(+)-pinanediolCF3COOH

Product name

(R)-Boroleu-(+)-pinanediolCF3COOH

CAS No.

179324-87-9

Molecular weight

379.23

Molecular Formula

C15H28BNO2.C2HF3O2

Appearance

white crystalline powder

Assay

99%min.

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