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Precautions For Intravenous Injection Of Amphotericin B Precautions For Intravenous Injection Of Amphotericin B

Amphotericin B Note the amphotericin B traits of yellow or orange powder for sensitive fungi caused by deep fungal infections and the progressive development of the disease, such as sepsis, endocarditis, meningitis, Abdominal infection, lung infection, urinary tract infection and endophthalmitis.
  • intravenous infusion of sterile water for injection 5ml preparation of this product 25mg, and then diluted with 5% glucose injection (not available sodium chloride injection, due to precipitation), diluted with glucose injection pH Should be above 4-2.
  • Infusion liquid concentration of not more than lOmg / lOOml, the selection of dark bags and dark infusion, the infusion pump slow light infusion, the correct liquid speed, each infusion time of 6 hours or more.
  • In the intravenous infusion of amphotericin B, should be selected rough blood vessels, to avoid liquid extravasation. During the course of treatment should be patrolled, observe the infusion of local conditions, in the event of injection site swelling, pain and other liquid extravasation, should immediately stop infusion, treatment of local skin, timely replacement of blood vessels, notify the doctor. Necessary physical therapy.
  • infusion of amphotericin B, should be strictly recorded out and urine test pH value.
  • monitoring blood pressure, close observation of changes in condition

medicine interactions

  • Adrenocorticotropic hormone, such drugs in the control of amphotericin B adverse drug reactions can be combined, but generally not recommended both at the same time, because of aggravating amphotericin B-induced hypokalemia. For the same use of adrenal cortex hormone should be the minimum dose and shortest course of treatment, and patients need to monitor serum potassium concentration and cardiac function.
  • Digoxigenin, hypokalemia caused by this product may enhance the potential of digitalis toxicity. Both should be closely monitored with the serum potassium concentration and cardiac function.
  • Flucytosine and amphotericin B have a synergistic effect, but this product can increase the cellular uptake of the former and impair their renal excretion, thereby enhancing the toxicity of flucytosine.
  • This product and pyrrole antifungal agents such as ketoconazole, fluconazole, itraconazole and other antagonistic effects in vitro.
  • Aminoglycosides, anti-tumor drugs, capreomycin, polymyxins, vancomycin and other nephrotoxic drugs with this product can enhance its nephrotoxicity.
  • Bone marrow inhibitors, radiation therapy can aggravate anemia in patients with amphotericin B should reduce the dose.
  • This product-induced hypokalemia can enhance the role of neuromuscular blocking drugs, the two need to monitor the concentration of serum potassium.
  • Application of alkalized urine can enhance the excretion of this product, and prevent or reduce the possibility of renal tubular acidosis.
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